USF vs. Old Dominion Cure Bowl Prediction & Odds

Rice v South Florida

Photo: Julio Aguilar / Getty Images Sport / Getty Images

The Cure Bowl will feature the South Florida Bulls squaring off against the Old Dominion Monarchs on Wednesday, December 17, 2025.

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South Florida vs. Old Dominion Matchup Info

  • Game date: Wednesday, December 17, 2025
  • Game time: 5 p.m. ET
  • Location: Orlando, Florida
  • Venue: Camping World Stadium
  • TV channel: ESPN

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South Florida vs. Old Dominion Odds and Prediction

  • Spread favorite: Bulls (-7.5)
  • Moneyline: Bulls (-300), Monarchs (+240)
  • Total: 55.5 points
  • Pick ATS: South Florida (-7.5)
  • Pick OU: Over (55.5)
  • Prediction: South Florida 34, Old Dominion 24

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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South Florida vs. Old Dominion Betting Records and Insights

  • South Florida has covered eight times in 12 chances against the spread this season.
  • Old Dominion is 7-5-0 ATS this season.
  • When playing as at least 7.5-point favorites this season, the Bulls have an ATS record of 5-1-1.
  • The Monarchs have covered the spread when playing as at least 7.5-point underdogs in their only opportunity this season.
  • South Florida games have hit the over seven out of 12 times this season.
  • In 2025, five Old Dominion games have hit the over.

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